(23-04-07) Obesity is the Major Determinant of the Abnormalities in Blood Pressure Found in Young Women with the Polycystic Ovary Syndrome.

Luque-Ramirez M, Alvarez-Blasco F, Mendieta-Azcona C, Botella-Department of Endocrinology, Hospital Universitario Ramon y Cajal & Univeridad de Alcala, (M.L.-R., F.A.-B, J.I.B.-C, H.F.E.-M) and Department of Vascular Surgery, Hospital Universitario La Paz (C.M.-A), Madrid, Spain.

Context. Obesity and insulin resistance predispose patients with the polycystic ovary syndrome (PCOS) to abnormalities in blood pressure regulation Objective. To evaluate the impact of obesity on the blood pressure profiles of PCOS patients Design. Case-control study Settings. Academic hospital Patients. Thirty-six PCOS patients and 20 healthy women. Main Outcome Measures. Ambulatory blood pressure monitoring (ABPM) and office blood pressure determinations Results. Hypertension (defined as increased office blood pressure confirmed by ABPM or by masked hypertension), was present in 12 PCOS patients and 8 controls (P = 0.618). No differences between patients and controls were found in office and ABPM blood pressure values and heart rate, yet the nocturnal decrease in mean blood pressure was smaller in patients (P = 0.038). Obese women (13 patients and 8 controls) had increased frequencies of office hypertension (29% compared with 3% in lean women, P = 0.005), increased diastolic (P = 0.009) and mean (P = 0.015) office blood pressure values, and increased heart rates values during the daytime (P = 0.038), nighttime (P = 0.002) and 24-hour (P= 0.009) periods, independently of having or not PCOS. The frequency of a nocturnal non-dipper pattern was 62% in obese PCOS patients, compared with 26% in lean PCOS patients (P = 0.036) and 25% in obese and lean controls. Conclusions. Abnormalities in the regulation of blood pressure are common in young women with PCOS yet, with the exception of the non-dipper pattern, these abnormalities result from the frequent association of this syndrome with obesity.

Source: J Clin Endocrinol Metab. 2007 Mar 27; [Epub ahead of print] Related Articles, Links

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