Seguici su acebook facebook Cerca nel sito:

Le news di Gerona 2005

(22-08-2018) Dietary curcumin supplementation attenuates inflammation, hepatic injury and oxidative damage in a rat model of intra-uterine growth retardation.





He J1,Niu Y1,Wang F1,Wang C1,Cui T1,Bai K1,Zhang J1,Zhong X1,Zhang L1,Wang T1.

Abstract

Rats with a normal birth weight (NBW) or intra-uterine growth retardation (IUGR) were fed basic diets (NBW and IUGR groups) or basic diets supplemented with curcumin (NC and IC groups) from 6 to 12 weeks. The body weight of IUGR rats was lower (P<0·05) than that of the controls. Rats with IUGR showed higher (P<0·05) concentrations of TNF-α, IL-1β and IL-6; higher (P<0·05) activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in their serum; and increased (P<0·05) concentrations of malondialdehyde (MDA), protein carbonyl (PC) and 8-hydroxy-2'-deoxyguanosine (8-OHDG) in the liver compared with the NBW rats. The livers of IUGR rats exhibited a lower (P<0·05) superoxide dismutase activity and decreased (P<0·05) metabolic efficiency of the hepatic glutathione redox cycle compared with those of the NBW rats. In response to dietary curcumin supplementation, concentrations of inflammatory cytokines and activities of AST and ALT in the serum and MDA, PC and 8-OHDG in the liver were lower (P<0·05), and the hepatic glutathione redox cycle in the liver was improved (P<0·05) in the IC group than in the IUGR group. These results were associated with lower (P<0·05) phosphorylated levels of the NF-κB pathway and Janus kinase 2 (JAK2) and higher (P<0·05) mRNA expression of genes involved in the nuclear factor, erythroid 2-like 2 (Nfe2l2)/antioxidant response element (ARE) pathway in the liver of the IC rats than that of the IUGR rats. Maternal undernutrition decreased birth weight and led to inflammation, oxidative damage and injury in rats. Curcumin appeared to be beneficial in preventing IUGR-induced inflammation, oxidative damage and injury by activating the expression of the NF-κB, JAK/STAT and Nfe2l2/ARE pathways in the liver.

Source: Br J Nutr.2018 Jul 25:1-12. doi: 10.1017/S0007114518001630. [Epub ahead of print]

News

  • (30-08-2018) The electronics in fluorescent bulbs and light emitting diodes (LED), rather than ultraviolet radiation, cause increased malignant melanoma incidence in indoor office workers and tanning bed users

    Leggi tutto

  • (30-08-2018) Mitocondri e peso forma

    Leggi tutto

  • (29-08-2018) Stroke now impacting younger patients as a result of the obesity epidemic; 4 in 10 are now aged 40-69

    Leggi tutto

  • (29-08-2018) Perdere peso non vuol dire perdere osso!

    Leggi tutto

  • (29-08-2018) Brain cholesterol: long secret life behind a barrier.

    Leggi tutto

  • (29-08-2018) Stile di vita sano? Si può, basta usare la fantasia

    Leggi tutto

  • (22-08-2018) Top 10 medical treatments that can make you SICKER than before you took them

    Leggi tutto

  • (22-08-2018) Meno ansia - C’è una associazione tra dieta e disturbi mentali?

    Leggi tutto

  • (22-08-2018) Dietary curcumin supplementation attenuates inflammation, hepatic injury and oxidative damage in a rat model of intra-uterine growth retardation.

    Leggi tutto

  • (22-08-2018) Dopo la gravidanza - Una dieta a basso indice glicemico se serve perdere peso

    Leggi tutto

  • (21-08-2018) Sleep Disturbances Can Be Prospectively Observed in Patients with an Inactive Inflammatory Bowel Disease.

    Leggi tutto

  • (21-08-2018) Anche i neo-papà soffrono della depressione post partum

    Leggi tutto


In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.

Informazioni utili